Low-Dose Naltrexone In San Diego, California

Name: Adonis Saremi, MD
Address: 888 Prospect St Suite 200, La Jolla, CA, 92037, US
Telephone: 619-736-1748
Rating: 5

At Adonis Saremi, MD, we specialize in providing Low-Dose Naltrexone (LDN) therapy in San Diego, a treatment designed to support patients with autoimmune conditions, chronic pain, and inflammation. Our clinic focuses on delivering personalized care, beginning with a detailed assessment of your medical history and current health status to determine the ideal LDN dosage.

We guide patients through the entire treatment process, including safe administration, ongoing monitoring, and adjustments to maximize results. By combining evidence-based protocols with individualized support, our team helps patients experience reduced symptoms and enhanced overall well-being, all while prioritizing safety and long-term health outcomes.

Choose a telemedicine visit or concierge home care to begin your LDN therapy without any delay!

Low-Dose

What Is Low-Dose Naltrexone?

Low-Dose Naltrexone (LDN) is a medical treatment that uses very small amounts of the medication naltrexone, typically about one-tenth of the standard dose. Naltrexone itself was originally developed to help people struggling with alcohol and opioid dependence. However, when given in low doses, it works very differently. Instead of blocking the effects of these substances, LDN interacts with the body’s endorphin system to gently “reset” how the immune system and nervous system respond.

This approach is being explored for its potential in reducing inflammation, calming overactive immune responses, and supporting the body’s natural healing abilities. Many patients who use LDN are not seeking addiction treatment but are instead looking for help with conditions like chronic pain, autoimmune disorders, or long-standing fatigue.

What Are The Benefits Of Low-Dose Naltrexone?

Helps Regulate The Immune System

LDN appears to modulate immune activity by increasing the number and function of T-regulatory (Treg) cells. These cells act like “peacekeepers” that prevent the immune system from mistakenly attacking healthy tissue. In autoimmune conditions, where the immune system is overactive, LDN helps restore balance without suppressing immunity entirely, unlike steroids or strong immunosuppressants.

Reduces Chronic Inflammation At The Cellular Level

When taken at very low doses, naltrexone briefly blocks opioid receptors in the brain and body. This short “blockade” tricks the body into producing more endorphins and enkephalins, which are natural painkillers with strong anti-inflammatory effects. Increased endorphins help lower levels of inflammatory chemicals like cytokines (e.g., TNF-α, IL-6), which drive pain and tissue damage in chronic conditions.

Supports Neurological Health By Calming Overactive Microglia

In the nervous system, immune cells called microglia can become overactive due to injury, infection, or autoimmune disease. Overactive microglia release toxic chemicals that damage neurons and worsen pain, fatigue, or cognitive issues. LDN works as a glial cell modulator, reducing harmful activity and protecting nerve pathways, which may explain its benefits in multiple sclerosis, fibromyalgia, and even Parkinson’s disease research.

Provides Safer Pain Management Without Dependency

Traditional opioids carry the risk of tolerance and addiction. LDN takes the opposite approach: by encouraging the body to upregulate its own natural opioid production, it strengthens endogenous pain-control systems without creating chemical dependency. Patients with neuropathic pain, inflammatory bowel disease, and chronic fatigue often find sustained relief without the side effects of stronger painkillers.

Promotes Better Mood And Sleep Through Endorphin Balance

Endorphins don’t just help with pain; they also play a role in regulating mood, stress, and sleep cycles. Low levels of endorphins have been linked to depression and insomnia. By boosting natural endorphin release, LDN can enhance feelings of well-being, reduce stress-related symptoms, and improve sleep quality, particularly in patients struggling with chronic illness.

Why Choose Adonis Saremi, MD, For Low-Dose Naltrexone?

Experienced Medical Team

Our team, under the guidance of Dr. Adonis Saremi, has extensive experience in internal medicine and chronic condition management, which is essential for prescribing and monitoring Low-Dose Naltrexone. Our team stays current with the latest clinical research on LDN’s role in autoimmune disorders, pain syndromes, and neurological conditions, so patients benefit from evidence-based care.

Personalized Treatment Plans

Every patient’s health background and treatment goals are different, which is why we don’t use a one-size-fits-all approach. At our clinic, we begin with a comprehensive evaluation of your medical history, lab work, and current symptoms. Based on these findings, Dr. Saremi develops a tailored LDN protocol that fits your needs, whether that means adjusting dosage schedules, combining LDN with other supportive therapies, or monitoring your progress with follow-ups. This individualized plan helps maximize benefits while minimizing side effects.

Convenient Location In San Diego, CA

Our clinic is centrally located in San Diego, making it easy for patients from across the city and surrounding areas to access care. The facility is designed to offer both comfort and efficiency, with modern diagnostic tools that support LDN therapy monitoring. For patients managing chronic conditions, having a reliable and accessible clinic nearby means ongoing treatment can be maintained without unnecessary stress.

We also offer complementary care options, including personalized in-home weight loss services San Diego patients rely on, designed to support whole-body wellness. To get started, book your appointment today by choosing your preferred date and time, or reach us directly at 619-736-1748 or info@adonissaremimd.com!

FAQ’s

How long does it take low-dose naltrexone to work?

Most patients notice improvements within 4–8 weeks, though response varies. Some experience earlier relief, while others may need longer for optimal symptom control.

Does low-dose naltrexone cause weight loss?

LDN is not a weight loss medication. However, by reducing inflammation and improving energy, some patients indirectly experience better weight management and metabolic balance.

What is the mechanism of low-dose naltrexone?

LDN temporarily blocks opioid receptors, stimulating increased endorphin release. This boosts immune regulation, reduces inflammation, and calms overactive microglial cells linked to pain and autoimmune activity.

What should I avoid when taking low-dose naltrexone?

Opioid medications should be avoided because LDN blocks their effect. At Adonis Saremi, MD, we carefully review all your prescriptions and supplements to ensure your treatment remains safe and effective.

Why is personalized dosing important, and how is it handled clinically?

Every patient responds differently to LDN. At Adonis Saremi, MD, we customize dosing, begin with careful titration, and adjust based on your progress to ensure maximum benefit with minimal side effects.